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Chapter 13:  Opioids-Advanced Topics

 

Review:

morphine

meperidine

 

fentanyl

sufentanil

alfentail

Opioid Structural Classifications

Papaver somniferum

oxymorphone

oxycodone

 

heroin

naloxone

 

1Notice the difference between agonist and partial agonist maximal effects (Fig 10-2, ref. 1)

Structure-Activity Relationships

1Morphine (left) exhibiting the "T" shape of the fundamental phenylpiperidine structure (Fig. 10-3, ref 1)

 

2T-Shape opioid molecule conformations (Fig 14-2, ref 2)

 

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