Coronary Vasodilators

Chapter 10:  Antianginal Drugs

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Increases in NO activate guanylyl cyclase causing increased formation of cGMP and vasodilation. The precise mechanisms by which cGMP relaxes vascular smooth muscle is unclear; however, cGMP can activate a cGMP-dependent protein kinase, activat K+ channels, decrease IP3, and inhibit calcium entry into the vascular smooth muscle -http://www.oucom.ohiou.edu/CVPhysiology/index.htm; 1999 Richard E. Klabunde, used with permission

Stoelting, R.K., "Peripheral Vasodilators", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, pp. 313-315.

Angina: Definition and Causes

Prinzmetal's variant angina
  • This figure illustrates coronary artery vasospasm.
  • In the top frame a localized narrowing of a long segment of the proximal right coronary artery is apparent.
  •  The patient had been complaining of intermittent chest pain during at rest.
  • In the bottom frame the abnormality has been corrected by intracoronary nitroglycerin.
  • The response to nitroglycering confirms that the narrowing resulted from coronary vasospasm or Prinzmetal's angina.

[Timmis, A.D. In Pocket Picture Guides: Cardiology, Gower Medical Publishing, London, 1985, p.21]

 

[Raehl, C.L., and Nolan, P.E. Ischemic Heart Disease: Anginal Syndromes in Applied Therapeutics: The Clinical Use of Drugs (Young, L.Y., and Koda-Kimble, M.A., eds), Applied Therapeutics, Inc., Vancouver, 1995, p 13-3.]

[Selwyn, A.P. and Braunwald, E Ischemic Heart Disease in Harrison's Principles of Internal Medicine (Isselbacher et al., eds) McGraw-Hill, Inc., New York, 1994, p 1077]

Factors Influencing Myocardial Oxygen Supply and Demand

Guyton, A.C. and Hall, J.E. in Textbook of Medical Physiology, W.B. Saunders & Co., Philadephia, 1984, p 258-259.

Selwyn, A.P. and Braunwald, E Ischemic Heart Disease in Harrison's Principles of Internal Medicine (Isselbacher et al., eds) McGraw-Hill, Inc., New York, 1994, p 1081-2.

[Selwyn, A.P. and Braunwald, E Ischemic Heart Disease in Harrison's Principles of Internal Medicine (Isselbacher et al., eds) McGraw-Hill, Inc., New York, 1994, p 1082]

Pharmacology of the Nitrates

[Robertson, R. M. and Robertson, D., Drugs Used for the Treatment of Myocardial Ischemia In: Goodman and Gilman's The Pharmacological Basis of Therapeutics (Hardman et al., eds), McGraw-Hill, New York, 1996, p. 762.

[Robertson, R. M. and Robertson, D., Drugs Used for the Treatment of Myocardial Ischemia In: Goodman and Gilman's The Pharmacological Basis of Therapeutics (Hardman et al., eds), McGraw-Hill, New York, 1996, p. 764]

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[Robertson, R. M. and Robertson, D., Drugs Used for the Treatment of Myocardial Ischemia In:Goodman and Gilman's The Pharmacological Basis of Therapeutics (Hardman et al., eds),McGraw-Hill, New York, 1996, p. 767-773]

[Robertson, R. M. and Robertson, D., Drugs Used for the Treatment of Myocardial Ischemia In:Goodman and Gilman's The Pharmacological Basis of Therapeutics (Hardman et al., eds),McGraw-Hill, New York, 1996, p. 767-773]

Clinical Pharmacology of Antianginal Agents

[Robertson, R. M. and Robertson, D., Drugs Used for the Treatment of Myocardial Ischemia In:Goodman and Gilman's The Pharmacological Basis of Therapeutics (Hardman et al., eds),McGraw-Hill, New York, 1996, p. 774-775]

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